Association of PCSK1 rs6234 with obesity and related traits in a Chinese Han population.

ABSTRACT:

Background

Common variants in PCSK1 have been reported to be associated with obesity in populations of European origin. We aimed to replicate this association in Chinese.

Methodology/principal findings

Two PCSK1 variants rs6234 and rs6235 (in strong LD with each other, r(2) = 0.98) were genotyped in a population-based cohort of 3,210 Chinese Hans. The rs6234 was used for further association analyses with obesity and related traits. We found no significant association of rs6234 with obesity, overweight, BMI, waist circumference, or body fat percentage (P > 0.05) in all participants. However, the rs6234 G-allele showed a significant association with increased risk of combined phenotype of obesity and overweight (OR 1.21[1.03-1.43], P = 0.0193) and a trend toward association wi

SUBMITTER: Qi Q 

PROVIDER: S-EPMC2871798 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature