Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy.

ABSTRACT:

Purpose

Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical model is developed to describe the spread of herpes simplex virus from the initial injection site.

Experimental design

The tumor is modeled as a sphere of radius R. The model incorporates reversible binding, interstitial diffusion, viral degradation, and internalization and physiologic parameters. Three species are considered as follows: free interstitial virus, virus bound to cell surfaces, and internalized virus.

Results

This analysis reveals that both rapid binding and internalization as well as hindered diffusion contain the virus to the initial in

SUBMITTER: Mok W 

PROVIDER: S-EPMC2872130 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature