Altered pain and thermal sensation in subjects with isolated parietal and insular cortical lesions.

ABSTRACT: Studies of sensory function following cortical lesions have often included lesions which multiple cortical, white matter, and thalamic structures. We now test the hypothesis that lesions anatomically constrained to particular insular and parietal structures and their subjacent white matter are associated with different patterns of sensory loss. Sensory loss was measured by quantitative sensory testing (QST), and evaluated statistically within patients relative to normal values. All seven subjects with insular and/or parietal lesions demonstrated thermal hypoesthesia, although the etiology of the lesions was heterogeneous. Cold and heat hypoalgesia were only found in the subject with the most extensive parietal and insular lesion, which occurred in utero. Cold allodynia occurred clinically

SUBMITTER: Veldhuijzen DS 

PROVIDER: S-EPMC2872197 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature