Usefulness of Mendelian randomization in observational epidemiology.

ABSTRACT: Mendelian randomization refers to the random allocation of alleles at the time of gamete formation. In observational epidemiology, this refers to the use of genetic variants to estimate a causal effect between a modifiable risk factor and an outcome of interest. In this review, we recall the principles of a "Mendelian randomization" approach in observational epidemiology, which is based on the technique of instrumental variables; we provide simulations and an example based on real data to demonstrate its implications; we present the results of a systematic search on original articles having used this approach; and we discuss some limitations of this approach in view of what has been found so far.

SUBMITTER: Bochud M 

PROVIDER: S-EPMC2872313 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature