Notch-activated signaling cascade interacts with mitochondrial remodeling proteins to regulate cell survival.

ABSTRACT: Survival of differentiated cells is one of several processes regulated by Notch activity, although the general principles underlying this function remain to be characterized. Here, we probe the mechanism underlying Notch-mediated survival, building on emerging evidence that apoptotic responses coordinated by specialized intermediates converge on mitochondria, identifying a core event in death pathways. The Bcl-2 family protein Bax is one such intermediate, which in a unifying response to diverse apoptotic stimuli nucleates multiprotein assemblies on mitochondria, committing cells to irrevocable damage. Using Bax as the prototype stimulus, we analyze Notch signaling for potential interactions with mitochondria, probe intrinsic properties of the Notch receptor, and describe key intermediates

SUBMITTER: Perumalsamy LR 

PROVIDER: S-EPMC2872423 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature