A genetic variant of hypoxia-inducible factor-1alpha is associated with adverse outcomes in acute kidney injury.

ABSTRACT: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that mediates many cellular responses to tissue hypoxia, a common feature of acute kidney injury (AKI). Here we studied 241 patients with AKI and determined the relationship to adverse outcome of a non-synonymous polymorphism in the coding region of the HIF-1alpha gene where a C to T substitution occurs at position +85 in exon 12, a change known to enhance transactivation. The baseline characteristics of the patients were not different among genotype groups except for a significantly higher prevalence of shock and number of failed organs in T-allele carriers. A significant genotype-phenotype association was found for plasma levels of vascular endothelial growth factor-A but not angiopoietin-2, two downstream targets of

SUBMITTER: Kolyada AY 

PROVIDER: S-EPMC2872511 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature