Co-ordinated gene expression in the liver and spleen during Schistosoma japonicum infection regulates cell migration.

ABSTRACT: Determining the molecular events induced in the spleen during schistosome infection is an essential step in better understanding the immunopathogenesis of schistosomiasis and the mechanisms by which schistosomes modulate the host immune response. The present study defines the transcriptional and cellular events occurring in the murine spleen during the progression of Schistosoma japonicum infection. Additionally, we compared and contrasted these results with those we have previously reported for the liver. Microarray analysis combined with flow cytometry and histochemistry demonstrated that transcriptional changes occurring in the spleen were closely related to changes in cellular composition. Additionally, the presence of alternatively activated macrophages, as indicated by up-regulation

SUBMITTER: Burke ML 

PROVIDER: S-EPMC2872641 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature