Mismatch repair protein expression and colorectal cancer in Hispanics from Puerto Rico.

ABSTRACT: Colorectal cancer (CRC) is a leading cause of morbidity and mortality and alterations in mismatch repair (MMR) genes, leading to absent protein (negative) expression, are responsible for approximately 20% of CRC cases. Immunohistochemistry is a tool for prescreening of MMR protein expression in CRC but the literature on its use on Hispanics is scarce. However, Hispanics represent the second leading ethnicity in the United States (US) and CRC is a public health burden in this group. Our objectives were to determine the frequency of MMR protein-negative CRC and to evaluate its association with clinical and pathological characteristics among Hispanics from Puerto Rico, for the first time to our knowledge. A retrospective observational study of unselected CRC patients from the Puerto Rico Medi

SUBMITTER: De Jesus-Monge WE 

PROVIDER: S-EPMC2873132 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature