Genetic aspects of adolescent idiopathic scoliosis in a family with multiple affected members: a research article.

ABSTRACT:

Background

The etiology of idiopathic scoliosis remains unknown and different factors have been suggested as causal. Hereditary factors can also determine the etiology of the disease; however, the pattern of inheritance remains unknown. Autosomal dominant, X-linked and multifactorial patterns of inheritances have been reported. Other studies have suggested possible chromosome regions related to the etiology of idiopathic scoliosis. We report the genetic aspects of and investigate chromosome regions for adolescent idiopathic scoliosis in a Brazilian family.

Methods

Evaluation of 57 family members, distributed over 4 generations of a Brazilian family, with 9 carriers of adolescent idiopathic scoliosis. The proband presented a scoliotic curve of 75 degrees, as determined by the

SUBMITTER: Wajchenberg M 

PROVIDER: S-EPMC2873229 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature