Phylogeny and expression of carbonic anhydrase-related proteins.

ABSTRACT:

Background

Carbonic anhydrases (CAs) are found in many organisms, in which they contribute to several important biological processes. The vertebrate alpha-CA family consists of 16 subfamilies, three of which (VIII, X and XI) consist of acatalytic proteins. These are named carbonic anhydrase related proteins (CARPs), and their inactivity is due to absence of one or more Zn-binding histidine residues. In this study, we analyzed and evaluated the distribution of genes encoding CARPs in different organisms using bioinformatic methods, and studied their expression in mouse tissues using immunohistochemistry and real-time quantitative PCR.

Results

We collected 84 sequences, of which 22 came from novel or improved gene models which we created from genome data. The distribution of C

SUBMITTER: Aspatwar A 

PROVIDER: S-EPMC2873310 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature