Integrated network analysis of transcriptomic and proteomic data in psoriasis.

ABSTRACT:

Background

Psoriasis is complex inflammatory skin pathology of autoimmune origin. Several cell types are perturbed in this pathology, and underlying signaling events are complex and still poorly understood.

Results

In order to gain insight into molecular machinery underlying the disease, we conducted a comprehensive meta-analysis of proteomics and transcriptomics of psoriatic lesions from independent studies. Network-based analysis revealed similarities in regulation at both proteomics and transcriptomics level. We identified a group of transcription factors responsible for overexpression of psoriasis genes and a number of previously unknown signaling pathways that may play a role in this process. We also evaluated functional synergy between transcriptomics and proteomics re

SUBMITTER: Piruzian E 

PROVIDER: S-EPMC2873316 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature