Low-complexity regions within protein sequences have position-dependent roles.

ABSTRACT:

Background

Regions of protein sequences with biased amino acid composition (so-called Low-Complexity Regions (LCRs)) are abundant in the protein universe. A number of studies have revealed that i) these regions show significant divergence across protein families; ii) the genetic mechanisms from which they arise lends them remarkable degrees of compositional plasticity. They have therefore proved difficult to compare using conventional sequence analysis techniques, and functions remain to be elucidated for most of them. Here we undertake a systematic investigation of LCRs in order to explore their possible functional significance, placed in the particular context of Protein-Protein Interaction (PPI) networks and Gene Ontology (GO)-term analysis.

Results

In keeping with previo

SUBMITTER: Coletta A 

PROVIDER: S-EPMC2873317 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature