A formal model for analyzing drug combination effects and its application in TNF-alpha-induced NFkappaB pathway.

ABSTRACT:

Background

Drug combination therapy is commonly used in clinical practice. Many methods including Bliss independence method have been proposed for drug combination design based on simulations models or experiments. Although Bliss independence method can help to solve the drug combination design problem when there are only a small number of combinations, as the number of combinations increases, it may not be scalable. Exploration of system structure becomes important to reduce the complexity of the design problem.

Results

In this paper, we deduced a mathematical model which can simplify the serial structure and parallel structure of biological pathway for synergy evaluation of drug combinations. We demonstrated in steady state the sign of the synergism assessment factor deriv

SUBMITTER: Yan H 

PROVIDER: S-EPMC2873319 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature