A 3D model of the membrane protein complex formed by the white spot syndrome virus structural proteins.

ABSTRACT:

Background

Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood. WSSV is a large enveloped virus. The WSSV virion has three structural layers surrounding its core DNA: an outer envelope, a tegument and a nucleocapsid. In this study, we investigated the protein-protein interactions of the major WSSV structural proteins, including several envelope and tegument proteins that are known to be involved in the infection process.

Principal findings

In the present report, we used coimmunoprecipitation and yeast two-hybrid assays to elucidate and/or confirm all the interactions that occur among the WSSV structural (envelope an

SUBMITTER: Chang YS 

PROVIDER: S-EPMC2873410 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature