The evolutionary diversification of LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages.

ABSTRACT:

Background

The transcription factors of the LSF/Grainyhead (GRH) family are characterized by the possession of a distinctive DNA-binding domain that bears no clear relationship to other known DNA-binding domains, with the possible exception of the p53 core domain. In triploblastic animals, the LSF and GRH subfamilies have diverged extensively with respect to their biological roles, general expression patterns, and mechanism of DNA binding. For example, Grainyhead (GRH) homologs are expressed primarily in the epidermis, and they appear to play an ancient role in maintaining the epidermal barrier. By contrast, LSF homologs are more widely expressed, and they regulate general cellular functions such as cell cycle progression and survival in addition to cell-lineage specific gene expre

SUBMITTER: Traylor-Knowles N 

PROVIDER: S-EPMC2873413 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature