Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans.

ABSTRACT:

Background

Intraflagellar transport (IFT) genes, which are critical for the development and function of cilia and flagella in metazoans, are tightly regulated by the Regulatory Factor X (RFX) transcription factors (TFs). However, how and when their evolutionary relationship was established remains unknown.

Results

We have identified evidence suggesting that RFX TFs and IFT genes evolved independently and their evolution converged before the first appearance of metazoans. Both ciliary genes and RFX TFs exist in all metazoans as well as some unicellular eukaryotes. However, while RFX TFs and IFT genes are found simultaneously in all sequenced metazoan genomes, RFX TFs do not co-exist with IFT genes in most pre-metazoans and thus do not regulate them in these organisms. For exa

SUBMITTER: Chu JS 

PROVIDER: S-EPMC2873420 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature