Cellular and molecular evidence for a role of tumor necrosis factor alpha in the ovulatory mechanism of trout.

ABSTRACT:

Background

The relevance of immune-endocrine interactions to the regulation of ovarian function in teleosts is virtually unexplored. As part of the innate immune response during infection, a number of cytokines such as tumor necrosis factor alpha (TNF alpha) and other immune factors, are produced and act on the reproductive system. However, TNF alpha is also an important physiological player in the ovulatory process in mammals. In the present study, we have examined for the first time the effects of TNF alpha in vitro in preovulatory ovarian follicles of a teleost fish, the brown trout (Salmo trutta).

Methods

To determine the in vivo regulation of TNF alpha expression in the ovary, preovulatory brook trout (Salvelinus fontinalis) were injected intraperitoneally with either s

SUBMITTER: Crespo D 

PROVIDER: S-EPMC2873445 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature