Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells.

ABSTRACT:

Background

Mesenchymal stem cells (MSC) are pluripotent cells, present in the bone marrow and other tissues that can differentiate into cells of all germ layers and may be involved in tissue maintenance and repair in adult organisms. Because of their plasticity and accessibility these cells are also prime candidates for regenerative medicine. The contribution of stem cell aging to organismal aging is under debate and one theory is that reparative processes deteriorate as a consequence of stem cell aging and/or decrease in number. Age has been linked with changes in osteogenic and adipogenic potential of MSCs.

Results

Here we report on changes in global gene expression of cultured MSCs isolated from the bone marrow of mice at ages 2, 8, and 26-months. Microarray analyses reve

SUBMITTER: Wilson A 

PROVIDER: S-EPMC2873471 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature