Functional dissection of translocon proteins of the Salmonella pathogenicity island 2-encoded type III secretion system.

ABSTRACT:

Background

Type III secretion systems (T3SS) are essential virulence factors of most Gram-negative bacterial pathogens. T3SS deliver effector proteins directly into the cytoplasm of eukaryotic target cells and for this function, the insertion of a subset of T3SS proteins into the target cell membrane is important. These proteins form hetero-oligomeric pores acting as translocon for the delivery of effector proteins. Salmonella enterica is a facultative intracellular pathogen that uses the Salmonella Pathogenicity Island 2 (SPI2)-encoded T3SS to manipulate host cells in order to survive and proliferate within the Salmonella-containing vacuole of host cells. Previous work showed that SPI2-encoded SseB, SseC and SseD act to form the translocon of the SPI2-T3SS.

Results

Here we

SUBMITTER: Holzer SU 

PROVIDER: S-EPMC2873485 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature