HIV-1 infection of macrophages is dependent on evasion of innate immune cellular activation.

ABSTRACT:

Objective

The cellular innate immune response to HIV-1 is poorly characterized. In view of HIV-1 tropism for macrophages, which can be activated via pattern recognition receptors to trigger antimicrobial defences, we investigated innate immune responses to HIV-1 by monocyte-derived macrophages.

Design

In a model of productive HIV-1 infection, cellular innate immune responses to HIV-1 were investigated, at the level of transcription factor activation, specific gene expression and genome-wide transcriptional profiling. In addition, the viral determinants of macrophage responses and the physiological effect of innate immune cellular activation on HIV-1 replication were assessed.

Results

Productive HIV-1 infection did not activate nuclear factor-kappaB and interferon regu

SUBMITTER: Tsang J 

PROVIDER: S-EPMC2873676 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature