Marijuana withdrawal and craving: influence of the cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH) genes.

ABSTRACT:

Aim

To examine whether withdrawal after abstinence and cue-elicited craving were associated with polymorphisms within two genes involved in regulating the endocannabinoid system, cannabinoid receptor 1 (CNR1) and fatty acid amide hydrolase (FAAH). Two single nucleotide polymorphisms (SNPs) in the CNR1 (rs2023239) and FAAH (rs324420) genes, associated previously with substance abuse and functional changes in cannabinoid regulation, were examined in a sample of daily marijuana smokers.

Participants

Participants were 105 students at the University of Colorado, Boulder between the ages of 18 and 25 years who reported smoking marijuana daily.

Measurements

Participants were assessed once at baseline and again after 5 days of abstinence, during which they were exposed to a c

SUBMITTER: Haughey HM 

PROVIDER: S-EPMC2873690 | biostudies-literature | 2008 Oct

REPOSITORIES: biostudies-literature