Immunomodulatory properties of stem cells from human exfoliated deciduous teeth.

ABSTRACT:

Introduction

Stem cells from human exfoliated deciduous teeth (SHED) have been identified as a population of postnatal stem cells capable of differentiating into osteogenic and odontogenic cells, adipogenic cells, and neural cells. Herein we have characterized mesenchymal stem cell properties of SHED in comparison to human bone marrow mesenchymal stem cells (BMMSCs).

Methods

We used in vitro stem cell analysis approaches, including flow cytometry, inductive differentiation, telomerase activity, and Western blot analysis to assess multipotent differentiation of SHED and in vivo implantation to assess tissue regeneration of SHED. In addition, we utilized systemic SHED transplantation to treat systemic lupus erythematosus (SLE)-like MRL/lpr mice.

Results

We found that SH

SUBMITTER: Yamaza T 

PROVIDER: S-EPMC2873699 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature