WD-repeat instability and diversification of the Podospora anserina hnwd non-self recognition gene family.

ABSTRACT:

Background

Genes involved in non-self recognition and host defence are typically capable of rapid diversification and exploit specialized genetic mechanism to that end. Fungi display a non-self recognition phenomenon termed heterokaryon incompatibility that operates when cells of unlike genotype fuse and leads to the cell death of the fusion cell. In the fungus Podospora anserina, three genes controlling this allorecognition process het-d, het-e and het-r are paralogs belonging to the same hnwd gene family. HNWD proteins are STAND proteins (signal transduction NTPase with multiple domains) that display a WD-repeat domain controlling recognition specificity. Based on genomic sequence analysis of different P. anserina isolates, it was established that repeat regions of all members of

SUBMITTER: Chevanne D 

PROVIDER: S-EPMC2873952 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature