An update on the genetics of atopic dermatitis: scratching the surface in 2009.

ABSTRACT: A genetic basis for atopic dermatitis (AD) has long been recognized. Historic documents allude to family history of disease as a risk factor. Before characterization of the human genome, heritability studies combined with family-based linkage studies supported the definition of AD as a complex trait in that interactions between genes and environmental factors and the interplay between multiple genes contribute to disease manifestation. A summary of more than 100 published reports on genetic association studies through mid-2009 implicates 81 genes, in 46 of which at least 1 positive association with AD has been demonstrated. Of these, the gene encoding filaggrin (FLG) has been most consistently replicated. Most candidate gene studies to date have focused on adaptive and innate immune respon

SUBMITTER: Barnes KC 

PROVIDER: S-EPMC2874322 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature