Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.

ABSTRACT:

Rationale

Much effort is being made to discover noninvasive biomarkers of chronic airway disease that might enable better management, predict prognosis, and provide new therapeutic targets.

Objectives

To undertake a comprehensive, unbiased proteomic analysis of induced sputum and identify novel noninvasive biomarkers for chronic obstructive pulmonary disease (COPD).

Methods

Induced sputum was obtained from patients with COPD with a spectrum of disease severity and from control subjects. Two-dimensional gel electrophoresis and mass spectrometric identification of differentially expressed proteins were first applied to induced sputum from patients with GOLD stage 2 COPD and healthy smoker control subjects. Initial results thus obtained were validated by a combination of

SUBMITTER: Nicholas BL 

PROVIDER: S-EPMC2874448 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature