Transcriptomic analysis identifies phosphatases as novel targets for adenotonsillar hypertrophy of pediatric obstructive sleep apnea.

ABSTRACT:

Rationale

Obstructive sleep apnea (OSA) is a highly prevalent disorder in children, in which enlarged adenotonsillar tissues (AT) play a major pathophysiologic role. Mechanisms leading to the proliferation and hypertrophy of AT in children who subsequently develop OSA remain unknown, and surgical extirpation of AT is associated with potential morbidity and mortality.

Objectives

We hypothesized that a computationally based analysis of gene expression in tonsils from children with OSA and children with recurrent tonsillitis without OSA can identify putative mechanistic pathways associated with tonsillar proliferation and hypertrophy in OSA.

Methods

Palatine tonsils from children with either polysomnographically documented OSA or recurrent infectious tonsillitis were sub

SUBMITTER: Khalyfa A 

PROVIDER: S-EPMC2874453 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature