The bone marrow-derived human mesenchymal stem cell: potential progenitor of the endometrial stromal fibroblast.

ABSTRACT: The cellular sources that contribute to the renewal of human endometrium are largely unknown. It has been suggested that endometrial stem cells originate from bone marrow-derived mesenchymal stem cells (MSC), with subsequent development into endometrial stromal fibroblasts (hESF). We hypothesized that if bone marrow-derived MSC contribute to endometrial regeneration and are progenitors of hESF, their treatment with agents known to regulate hESF differentiation could promote their differentiation down the stromal fibroblast lineage. To this end, we treated bone marrow-derived MSC with estradiol and progesterone, bone morphogenetic protein 2 (BMP2), and activators of the protein kinase A (PKA) pathway and investigated specific markers of hESF differentiation (decidualization). Furthermore, w

SUBMITTER: Aghajanova L 

PROVIDER: S-EPMC2874495 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature