Protection against LPS-induced cartilage inflammation and degradation provided by a biological extract of Mentha spicata.

ABSTRACT:

Background

A variety of mint [Mentha spicata] has been bred which over-expresses Rosmarinic acid (RA) by approximately 20-fold. RA has demonstrated significant anti-inflammatory activity in vitro and in small rodents; thus it was hypothesized that this plant would demonstrate significant anti-inflammatory activity in vitro. The objectives of this study were: a) to develop an in vitro extraction procedure which mimics digestion and hepatic metabolism, b) to compare anti-inflammatory properties of High-Rosmarinic-Acid Mentha spicata (HRAM) with wild-type control M. spicata (CM), and c) to quantify the relative contributions of RA and three of its hepatic metabolites [ferulic acid (FA), caffeic acid (CA), coumaric acid (CO)] to anti-inflammatory activity of HRAM.

Methods

HRAM a

SUBMITTER: Pearson W 

PROVIDER: S-EPMC2874512 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature