Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5.

ABSTRACT:

Background and purpose

The chemokine receptor CCR5 is well known for its function in immune cells; however, it is also expressed in the brain, where its specific role remains to be elucidated. Because genetic factors may influence the risk of developing cerebral ischaemia or affect its clinical outcome, we have analysed the role of CCR5 in experimental stroke.

Experimental approach

Permanent cerebral ischaemia was performed by occlusion of the middle cerebral artery in wild-type and CCR5-deficient mice. Locomotor behaviour, infarct size and histochemical alterations were analysed at different time points after occlusion.

Key results

The cerebral vasculature was comparable in wild-type and CCR5-deficient mice. However, the size of the infarct and the motor deficits aft

SUBMITTER: Sorce S 

PROVIDER: S-EPMC2874853 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature