WDTC1, the ortholog of Drosophila adipose gene, associates with human obesity, modulated by MUFA intake.

ABSTRACT: Adipose (adp) is an obesity gene in Drosophila and mice with crucial functions in fat metabolism. We investigated the correlation between genetic variation of the WDTC1 locus, the ortholog of adp, and human obesity. Five WDTC1 single-nucleotide polymorphisms (SNPs) were genotyped in 935 and 1,115 adults of two ethnically diverse US populations. In the Boston Puerto Rican population, we demonstrated that two WDTC1 SNPs strongly associated with obesity. Homozygote and heterozygote carriers of the major allele i22835A, representing approximately 96% of the population, had significantly higher mean BMI (31.5 and 31.0 kg/m(2), respectively) than noncarriers (28.6 kg/m(2)). Conversely, homozygotes of the minor allele i22835G were leaner and were 74% less likely to be overweight or obese (odds ra

SUBMITTER: Lai CQ 

PROVIDER: S-EPMC2874970 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature