Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling.

ABSTRACT: The cerebral cortex is a laminated sheet of neurons composed of the arrays of intersecting radial columns. During development, excitatory projection neurons originating from the proliferative units at the ventricular surface of the embryonic cerebral vesicles migrate along elongated radial glial fibres to form a cellular infrastructure of radial (vertical) ontogenetic columns in the overlaying cortical plate. However, a subpopulation of these clonally related neurons also undergoes a short lateral shift and transfers from their parental to the neighbouring radial glial fibres, and intermixes with neurons originating from neighbouring proliferative units. This columnar organization acts as the primary information processing unit in the cortex. The molecular mechanisms, role and significance

SUBMITTER: Torii M 

PROVIDER: S-EPMC2874978 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature