Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays.

ABSTRACT: In April 2009, a new influenza A (H1N1 2009) virus emerged that rapidly spread around the world. While current variants of this virus have caused widespread disease, particularly in vulnerable groups, there remains the possibility that future variants may cause increased virulence, drug resistance or vaccine escape. Early detection of these virus variants may offer the chance for increased containment and potentially prevention of the virus spread. We have developed and field-tested a resequencing kit that is capable of interrogating all eight segments of the 2009 influenza A(H1N1) virus genome and its variants, with added focus on critical regions such as drug-binding sites, structural components and mutation hotspots. The accompanying base-calling software (EvolSTAR) introduces novel met

SUBMITTER: Lee CW 

PROVIDER: S-EPMC2874996 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature