Translation efficiency in humans: tissue specificity, global optimization and differences between developmental stages.

ABSTRACT: Various studies in unicellular and multicellular organisms have shown that codon bias plays a significant role in translation efficiency (TE) by co-adaptation to the tRNA pool. Yet, in humans and other mammals the role of codon bias is still an open question, with contradictory results from different studies. Here we address this question, performing a large-scale tissue-specific analysis of TE in humans, using the tRNA Adaptation Index (tAI) as a direct measure for TE. We find tAI to significantly correlate with expression levels both in tissue-specific and in global expression measures, testifying to the TE of human tissues. Interestingly, we find significantly higher correlations in adult tissues as opposed to fetal tissues, suggesting that the tRNA pool is more adjusted to the adult pe

SUBMITTER: Waldman YY 

PROVIDER: S-EPMC2875035 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature