APOE epsilon4 and the cognitive genetics of multiple sclerosis.

ABSTRACT:

Background

Evidence linking APOE to myelin repair, neuronal plasticity, and cerebral inflammatory processes suggests that it may be relevant in multiple sclerosis (MS). The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS.

Method

Using a case-control design, 50 patients with MS with the epsilon4 allele (epsilon4+) and 50 epsilon4-negative (epsilon4-) patients with MS were tested using a comprehensive battery of tests evaluating the cognitive domains most often affected in MS.

Results

The epsilon4+ and epsilon4- patients with MS were well-matched with respect to demographic variables (age, gender, ethnicity, education, employment status, premorbid IQ) and disease variables (disease cour

SUBMITTER: Ghaffar O 

PROVIDER: S-EPMC2875133 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature