PTPN22: its role in SLE and autoimmunity.

ABSTRACT: A functional variant of protein tyrosine phosphatase nonreceptor 22 (PTPN22) has recently been shown to be associated with multiple autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, type 1 diabetes, and autoimmune thyroid disease. In this review, we discuss the structure and function of this gene and its disease-associated polymorphisms. In addition, we review the studies investigating the association between this gene and SLE, along with other autoimmune diseases.

SUBMITTER: Chung SA 

PROVIDER: S-EPMC2875134 | biostudies-literature | 2007 Dec

REPOSITORIES: biostudies-literature