Sequence features involved in the mechanism of 3' splice junction wobbling.

ABSTRACT:

Background

Alternative splicing is an important mechanism mediating the diversified functions of genes in multicellular organisms, and such event occurs in around 40-60% of human genes. Recently, a new splice-junction wobbling mechanism was proposed that subtle modifications exist in mRNA maturation by alternatively choosing at 5'- GTNGT and 3'- NAGNAG, which created single amino acid insertion and deletion isoforms.

Results

By browsing the Alternative Splicing Database information, we observed that most 3' alternative splice site choices occur within six nucleotides of the dominant splice site and the incidence significantly decreases further away from the dominant acceptor site. Although a lower frequency of alternative splicing occurs within the intronic region (alternati

SUBMITTER: Tsai KW 

PROVIDER: S-EPMC2875228 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature