Divergence of imprinted genes during mammalian evolution.

ABSTRACT:

Background

In contrast to the majority of mammalian genes, imprinted genes are monoallelically expressed with the choice of the active allele depending on its parental origin. Due to their special inheritance patterns, maternally and paternally expressed genes might be under different evolutionary pressure. Here, we aimed at assessing the evolutionary history of imprinted genes.

Results

In this study, we investigated the conservation of imprinted genes in vertebrate genomes and their exposition to natural selection. In a genome-wide comparison, orthologs of imprinted genes show a stronger divergence on cDNA and protein level in mammals. This pattern is most pronounced for maternally expressed genes in rodents in comparison to their non-rodent orthologs. The divergence is not

SUBMITTER: Hutter B 

PROVIDER: S-EPMC2875234 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature