Genome response to tissue plasminogen activator in experimental ischemic stroke.

ABSTRACT:

Background

Tissue plasminogen activator (tPA) is known to have functions beyond fibrinolysis in acute ischemic stroke, such as blood brain barrier disruption. To further delineate tPA functions in the blood, we examined the gene expression profiles induced by tPA in a rat model of ischemic stroke.

Results

tPA differentially expressed 929 genes in the blood of rats (p or= |1.2|). Genes identified had functions related to modulation of immune cells. tPA gene expression was found to be dependent on the reperfusion status of cerebral vasculature. The majority of genes regulated by tPA were different from genes regulated by ischemic stroke.

Conclusions

tPA modulates gene expression in the blood of rats involving immune cells in a manner that is depe

SUBMITTER: Jickling GC 

PROVIDER: S-EPMC2875237 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature