Global transcriptome analysis of spore formation in Myxococcus xanthus reveals a locus necessary for cell differentiation.

ABSTRACT:

Background

Myxococcus xanthus is a Gram negative bacterium that can differentiate into metabolically quiescent, environmentally resistant spores. Little is known about the mechanisms involved in differentiation in part because sporulation is normally initiated at the culmination of a complex starvation-induced developmental program and only inside multicellular fruiting bodies. To obtain a broad overview of the sporulation process and to identify novel genes necessary for differentiation, we instead performed global transcriptome analysis of an artificial chemically-induced sporulation process in which addition of glycerol to vegetatively growing liquid cultures of M. xanthus leads to rapid and synchronized differentiation of nearly all cells into myxospore-like entities.

Result

SUBMITTER: Muller FD 

PROVIDER: S-EPMC2875238 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature