A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys.

ABSTRACT:

Background

Variation at the human mu-opioid receptor has been associated with alcohol abuse. The A118G (N40D) polymorphism in humans is functionally mimicked by the C77G (P26R) polymorphism in rhesus monkeys; both show similar in vitro influences on ligand binding and in vivo correlations with physiological measures as well as behavioral measures including predilection towards alcohol consumption. Naltrexone, an antagonist at the receptor, has been used to treat alcoholism in humans and has been reported to show differences in effectiveness depending on genotype.

Methods

Here we describe a study in which we a priori selected rhesus monkeys based on genotype at the OPRM1 C77G single nucleotide polymorphism, trained them to self-administer alcohol, and assessed naltrexone resp

SUBMITTER: Vallender EJ 

PROVIDER: S-EPMC2875311 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature