Trafficking through COPII stabilises cell polarity and drives secretion during Drosophila epidermal differentiation.

ABSTRACT:

Background

The differentiation of an extracellular matrix (ECM) at the apical side of epithelial cells implies massive polarised secretion and membrane trafficking. An epithelial cell is hence engaged in coordinating secretion and cell polarity for a correct and efficient ECM formation.

Principal findings

We are studying the molecular mechanisms that Drosophila tracheal and epidermal cells deploy to form their specific apical ECM during differentiation. In this work we demonstrate that the two genetically identified factors haunted and ghost are essential for polarity maintenance, membrane topology as well as for secretion of the tracheal luminal matrix and the cuticle. We show that they code for the Drosophila COPII vesicle-coating components Sec23 and Sec24, respectively,

SUBMITTER: Norum M 

PROVIDER: S-EPMC2875407 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature