Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort.

ABSTRACT:

Objective

To assess whether TCF7L2 polymorphism has a role in the deterioration of glycemic control.

Research design and methods

Metabolic variables were evaluated at baseline and after 6-year follow-up in 1,480 Caucasian subjects from a population-based cohort.

Results

At baseline, T-allele carriers showed significantly lower BMI and homeostasis model assessment for beta-cell function (HOMA-B) values and higher fasting glycemia and diabetes prevalence. At follow-up, fasting glucose and HOMA-B index were increased and reduced, respectively, in carriers of the T-allele. Incident impaired fasting glucose (IFG) and incident diabetes were 5.7, 10.7, 16.9% and 1.6, 1.7, 3.0% in the CC, CT, and TT genotypes, respectively. In a multiple logistic regression model, the associa

SUBMITTER: Gambino R 

PROVIDER: S-EPMC2875429 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature