Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations.

ABSTRACT:

Objective

To study trough levels of metformin in serum and its intra-individual variation in patients using a newly developed assay.

Research design and methods

Trough serum levels of metformin were measured once using liquid chromatography-tandem mass spectrometry (LCMSMS) in 137 type 2 diabetic patients with varying renal function (99 men) and followed repeatedly during 2 months in 20 patients (16 men) with estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2) body surface.

Results

Patients with eGFR >60, 30-60, and <30 ml/min/1.73 m(2) had median trough metformin concentrations of 4.5 micromol/l (range 0.1-20.7, n = 107), 7.71 micromol/l (0.12-15.15, n = 21), and 8.88 micromol/l (5.99-18.60, n = 9), respectively. The median intra-individual overall coeff

SUBMITTER: Frid A 

PROVIDER: S-EPMC2875440 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature