Correlation of pain relief with physical function in hand osteoarthritis: randomized controlled trial post hoc analysis.

ABSTRACT:

Introduction

Nonsteroidal anti-inflammatory drugs are recommended for the relief of pain associated with hand osteoarthritis (OA) but do not alter the underlying structural changes that contribute to impaired physical function. The current analysis examined the relationship of pain relief with measures of function and global rating of disease in patients with hand OA.

Methods

This was a combined analysis of 2 prospective, randomized, double-blind, 8-week, multicenter, parallel-group studies comparing diclofenac sodium 1% gel with placebo gel (vehicle) in patients with radiographically confirmed mild to moderate hand OA. Patients (n = 783) aged > or = 40 years applied diclofenac sodium 1% gel (2 g) or vehicle to each hand 4 times daily for 8 weeks. Outcome measures included p

SUBMITTER: Barthel HR 

PROVIDER: S-EPMC2875633 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature