The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis.

ABSTRACT:

Background

Degradation of the mitotic cyclins is a hallmark of the exit from mitosis. Induction of stable versions of each of the three mitotic cyclins of Drosophila, cyclins A, B, and B3, arrests mitosis with different phenotypes. We tested a recent proposal that the destruction of the different cyclins guides progress through mitosis.

Results

Real-time imaging revealed that arrest phenotypes differ because each stable cyclin affects specific mitotic events differently. Stable cyclin A prolonged or blocked chromosome disjunction, leading to metaphase arrest. Stable cyclin B allowed the transition to anaphase, but anaphase A chromosome movements were slowed, anaphase B spindle elongation did not occur, and the monooriented disjoined chromosomes began to oscillate between the

SUBMITTER: Parry DH 

PROVIDER: S-EPMC2875931 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature