Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.

ABSTRACT:

Background

Genome-wide studies have identified several common genetic variants that are robustly associated with adult obesity risk. Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity.

Methods and findings

Children from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were genotyped for ten genetic variants previously associated with adult BMI. Eight variants that showed individual associations with childhood BMI (in/near: FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, and ETV5) were used to derive an "obesity-risk-allele score" comprising the total number of risk alleles (range: 2-15 alleles) in each child with complete genotype data (n = 7,146). Repeated measuremen

SUBMITTER: Elks CE 

PROVIDER: S-EPMC2876048 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature