MUC1-associated proliferation signature predicts outcomes in lung adenocarcinoma patients.

ABSTRACT:

Background

MUC1 protein is highly expressed in lung cancer. The cytoplasmic domain of MUC1 (MUC1-CD) induces tumorigenesis and resistance to DNA-damaging agents. We characterized MUC1-CD-induced transcriptional changes and examined their significance in lung cancer patients.

Methods

Using DNA microarrays, we identified 254 genes that were differentially expressed in cell lines transformed by MUC1-CD compared to control cell lines. We then examined expression of these genes in 441 lung adenocarcinomas from a publicly available database. We employed statistical analyses independent of clinical outcomes, including hierarchical clustering, Student's t-tests and receiver operating characteristic (ROC) analysis, to select a seven-gene MUC1-associated proliferation signature (MAPS)

SUBMITTER: MacDermed DM 

PROVIDER: S-EPMC2876055 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature