A comparative genome analysis of gene expression reveals different regulatory mechanisms between mouse and human embryo pre-implantation development.

ABSTRACT:

Background

Pre-implantation development is a crucial step in successful implantation and pregnancy in mammals. It has been studied in depth, but mostly in laboratory animal models. Less is known about the regulatory mechanism involved in the pre-implantation development in humans and about the comparative aspects.

Methods

Here, we employed the microarray datasets from the public database library of GEO and applied comparative analysis of genome wide temporal gene expression data based on statistical analysis and functional annotation for both mouse and human, demonstrating the discordance between the regulatory mechanisms of both mouse and human pre-implantation development.

Results

There were differences between mouse and human pre-implantation development both in th

SUBMITTER: He K 

PROVIDER: S-EPMC2876170 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature