The relationship between smoking and replicated sequence variants on chromosomes 8 and 9 with familial intracranial aneurysm.

ABSTRACT:

Background and purpose

The purpose of this study was to replicate the previous association of single nucleotide polymorphisms (SNPs) with risk of intracranial aneurysm (IA) and to examine the relationship of smoking with these variants and the risk of IA.

Methods

White probands with an IA from families with multiple affected members were identified by 26 clinical centers located throughout North America, New Zealand, and Australia. White control subjects free of stroke and IA were selected by random digit dialing from the Greater Cincinnati population. SNPs previously associated with IA on chromosomes 2, 8, and 9 were genotyped using a TaqMan assay or were included in the Affymetrix 6.0 array that was part of a genomewide association study of 406 IA cases and 392 control sub

SUBMITTER: Deka R 

PROVIDER: S-EPMC2876230 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature