Prenatal acetaminophen exposure and risk of wheeze at age 5 years in an urban low-income cohort.

ABSTRACT:

Background

Acetaminophen has been associated with asthma and is in part metabolised via the glutathione pathway. Inner-city minority children have high asthma morbidity and a relatively high frequency of a minor allele variant in the glutathione S transferase Pi gene (GSTP1). We hypothesised that prenatal acetaminophen exposure would predict wheeze at age 5 years in an inner-city minority cohort and examined whether this association was modified by common polymorphisms in genes related to the glutathione pathway.

Methods

An ongoing population-based birth cohort study of Dominican Republic and African-American children in New York prospectively assessed the use of analgesics during pregnancy and current wheeze at age 5 years in 301 children. Genotyping was conducted for GST p

SUBMITTER: Perzanowski MS 

PROVIDER: S-EPMC2876309 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature